CAS 1670-26-4; sphingosyl-phosphorylcholine

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货号

品牌

产品名称

规格

包装、参考价格

D920884

MACKLIN

D-赤藓-鞘氨醇磷酸胆碱;神经鞘氨醇磷酸胆碱

>99%

3510元/5mg;

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储存：-20℃

860600P

Avanti

Lyso SM (d18:1)

Avanti Polar Lipids 860600P, powder

3369.59元/5 MG; 5123.78元/10 MG; 16947.8元/50 MG;

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产品说明

一般描述

Lyso SM (d18:1), also known as sphingosylphosphorylcholine (SPC), is a bioactive lipid molecule. This lysophospholipid is present in normal blood plasma, ascites and various tissues.

应用

Lyso SM (d18:1) has been used:

to study its effect on the skeletal muscle ryanodine receptor (RyR1), in the presence and absence of calmodulin through single channel recordings in planar lipid bilayers
as an inhibitor of Ca²⁺sensor calmodulin (CaM)
as a standard in circular dichroism (CD) spectroscopy to determine lipid selectivity of the lipid-peptide interactions

生化/生理作用

Lyso SM (d18:1) or sphingosylphosphorylcholine (SPC) is a lipid mediator that exhibits second messenger functions. It regulates ryanodine receptors (RyRs) and releases Ca²⁺ from the sarco/endoplasmic reticulum. Lyso SM (d18:1) acts as an endogenous inhibitor of ubiquitous Ca²⁺ sensor calmodulin (CaM).

包装

5 mL Amber Glass Screw Cap Vial (860600P-25mg)
5 mL Amber Glass Screw Cap Vial (860600P-50mg)
5 mL Amber Glass Screw Cap Vial (860600P-5mg)
5 mL Amber Glass Screw Cap Vial (860600P-10mg)

基本信息

经验(实验)分子式	C₂₃H₄₉N₂O₅P
分子量	464.62
NACRES	NA.25

产品性质

形式	powder
包装	pkg of 1 × 10 mg (860600P-10mg) pkg of 1 × 25 mg (860600P-25mg) pkg of 1 × 5 mg (860600P-5mg) pkg of 1 × 50 mg (860600P-50mg)
manufacturer/tradename	Avanti Polar Lipids 860600P
运输	dry ice
储存温度	−20℃
SMILES string	[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(N)COP([O-])(OCC[N+](C)(C)C)=O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

567735

Sigma-Aldrich

Sphingosylphosphoryl-choline-CAS 1670-26-4-Calbiochem

SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A.

6418.84元/10 MG;

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产品说明

一般描述

SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca²⁺and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125^FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss/3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.
SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca²⁺ and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125^FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss 3T3 cells. Also induces a unique reorganization of the actin cytoskeleton.

包装

10 mg in Plastic ampoule

生化/生理作用

Primary Target
A potent mitogen
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

其他说明

Berger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885.
Dettbarn, C., et al. 1995. Brain Res.669, 79.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343.
Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₃H₄₉N₂O₅P
分子量	464.62
MDL编号	MFCD02259287

产品性质

质量水平	100
测定	≥98% (TLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze desiccated
颜色	white
溶解性	chloroform/methanol (2:1): 1 mg/mL
运输	ambient
储存温度	−20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

S4257

Sigma-Aldrich

Sphingosylphosphorylcholine

≥98%, powder

3881.64元/10 MG; 7436.61元/25 MG;

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产品说明

应用

目前已研究了鞘氨醇磷酸胆碱对小鼠小脑颗粒神经元和PC-12细胞的神经营养作用。

包装

10 mg in poly bottle
25 mg in glass bottle

生化/生理作用

鞘氨醇磷酸胆碱(SPC)是一种介导细胞内和细胞外信号传导的生物活性脂质。它通过不依赖IP3的途径从细胞内储存物中调动Ca²⁺。它刺激CCL2生成，可能有助于动脉粥样硬化病情发展。SPC是内皮细胞分化基因受体3 (EDG3)的配体。

基本信息

经验(实验)分子式	C₂₃H₄₉N₂O₅P
分子量	464.62
Beilstein	7342520
MDL编号	MFCD02259287
PubChem化学物质编号	24899596
NACRES	NA.77

产品性质

质量水平	200
测定	≥98%
形式	powder
颜色	light yellow
溶解性	chloroform/methanol (2:1): complete 10 mg/ml, clear to slightly hazy, colorless to light yellow
储存温度	−20℃
SMILES string	[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(N)COP([O-])(OCC[N+](C)(C)C)=O
InChI	1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m0/s1
InChI key	JLVSPVFPBBFMBE-HXSWCURESA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)