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CAS: 1485-00-3
分子式: C9H7NO4
分子量: 193.16
熔点: >86 °C(dec.)
英文名称: 
3,4-methylenedioxy-beta-nitro-styren
5-nitrovinyl-3-benzodioxole
3,4-methylenedioxy-beta-nitrostyrene
用途: MNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)是一种酪氨酸激酶抑制剂,抑制Syk, Src和p97, IC50分别为2.5 μM, 29.3 μM和1.7 μM。
推荐供应商
货号品牌产品名称规格包装、参考价格
M793644MACKLINMNS (3, 4-Methylenedioxy-β-nitrostyrene, MDBN)10mM in DMSO185元/1ml;   咨询
储存:-20°C, 避光, 惰性气体
M873185MACKLINMNS (3,4-Methylenedioxy-β-nitrostyrene, MDBN)99%189元/1g;   710元/5g;   2286元/25g;   咨询
储存:-20℃
状态:浅黄色到黄色到棕色到绿色粉末到晶体
M3390TCIMNS>98.0%(GC)450元/100MG;   1550元/500MG;   咨询

基本信息

纯度/分析方法>98.0%(GC)
分子式/分子量C9H7NO4 = 193.16
外观与形状(20℃)固体
储存温度-20℃
储存在惰性气体下存放于惰性气体之中
应避免的情况光,空气,加热
Reaxys-RN15499
MDL编号MFCD00014575

技术规格

AppearanceLight yellow to Yellow to Green powder to crystal
Purity(GC)min. 98.0 %
Melting point159.0 to 163.0 ℃
NMRconfirm to structure

物性(参考值)

熔点161 ℃

安全信息

图形或危害标志
信号词警告
危险性说明H315 : 造成皮肤刺激。
H319 : 造成严重眼刺激。
防范说明P264 : 作业后彻底清洗皮肤。
P280 : 戴防护手套/戴防护眼罩/戴防护面具。
P302 + P352 : 如皮肤沾染:用水充分清洗。
P337 + P313 : 如仍觉眼刺激:求医/就诊。
P305 + P351 + P338 : 如进入眼睛:用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出,取出隐形眼镜。继续冲洗。
P362+P364 : 脱掉沾污的衣服,清洗后方可重新使用。
P332 + P313 : 如发生皮肤刺激:求医/就诊。

相关法规

RTECS#WL5270000
S3529183,4-Methylenedioxy-beta-nitrostyreneAldrichCPR1908.94元/250MG;   咨询

产品说明

其他说明

Please note that sigma-aldrich provides this product to early discovery researchers as part of a collection of rare and unique chemicals. sigma-aldrich does not collect analytical data for this product. Buyer assumes responsibility to confirm product identity and/or purity. All sales are final.

NOTWITHSTANDING ANY CONTRARY PROVISION CONTAINED IN SIGMA-ALDRICH'S STANDARD TERMS AND CONDITIONS OF SALE OR AN AGREEMENT BETWEEN SIGMA-ALDRICH AND BUYER, SIGMA-ALDRICH SELLS THIS PRODUCT AS-IS AND MAKES NO REPRESENTATION OR WARRANTY WHATSOEVER WITH RESPECT TO THIS PRODUCT, INCLUDING ANY (A) WARRANTY OF MERCHANTABILITY; (B) WARRANTY OF FITNESS FOR A PARTICULAR PURPOSE; OR (C) WARRANTY AGAINST INFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS OF A THIRD PARTY; WHETHER ARISING BY LAW, COURSE OF DEALING, COURSE OF PERFORMANCE, USAGE OF TRADE OR OTHERWISE.

基本信息

线性分子式C9H7NO4
分子量193.16
MDL编号MFCD00014575
574713Sigma-AldrichSyk Inhibitor III-CAS 1485-00-3-CalbiochemThe Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applica2165.23元/50 MG;   咨询

产品说明

一般描述

A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC50 = 2.5 µM). It inhibits Src only at much higher concentrations (IC50 = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC50 ranges from 2.1 to 25.9 µM).

包装

50 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
Syk
Target IC50: 2.5 µM against Syk kinase activity
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Wang, W.Y., et al. 2006. Mol. Pharmacol.70, 1380.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C9H7NO4
分子量193.16
MDL编号MFCD00014575

产品性质

质量水平100
测定≥98% (GC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 yellow to brown
溶解性DMSO: 25 mg/mL (Use only fresh DMSO.)
运输ambient
储存温度−20℃
InChI1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3-
InChI keyKFLWBZPSJQPRDD-ARJAWSKDSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319
预防措施声明P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
危险分类Eye Irrit. 2 - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
241702Fluorochem5-(2-nitrovinyl)benzo[d][1,3]dioxole95%1518元/10g;   6204元/50g;   咨询

基本信息

CAS Number1485-00-3
MDL NumberMFCD00014575
Boiling Point329.36℃
Melting Point158-160℃
Density1.4058

安全信息

图形或危害标志
危险性说明 H301: Toxic if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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