CAS 147385-61-3; leupeptin trifluoroacetate from*microbial source

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CAS:

147385-61-3

分子式:

C20H38N6O4

分子量:

426.55

英文名称:

leupeptin trifluoroacetate from*microbial source

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货号

品牌

产品名称

规格

包装、参考价格

L921684

MACKLIN

亮肽素三氟乙酸盐

≥90% (HPLC)

343元/1mg;

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储存：−20°C
状态：固体

L2023

Sigma-Aldrich

Leupeptin trifluoroacetate salt

≥90% (HPLC), microbial

370.26元/1 MG; 1561.46元/5 MG; 2655.32元/10 MG; 4874.24元/25 MG; 8538.73元/50 MG;

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产品说明

包装

5, 10, 25, 50, 100 mg in glass bottle

生化/生理作用

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

分析说明

由于三种形式在溶液中达到平衡，亮抑酶肽可在 HPLC 上形成多个峰。通过三个主峰测定纯度。主要的杂质肽为外消旋亮抑酶肽。

基本信息

经验(实验)分子式	C₂₀H₃₈N₆O₄ · xC₂HF₃O₂
分子量	426.55 (free base basis)
MDL编号	MFCD00133458
PubChem化学物质编号	329817397
NACRES	NA.77

产品性质

质量水平	200
生物来源	microbial
测定	≥90% (HPLC)
形式	powder
溶解性	H₂O: 10 mM (Solutions are stable only a few hours. Stock solutions are stable up to 6 months at −20 ℃.)
储存温度	−20℃
SMILES string	OC(=O)C(F)(F)F.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O
InChI	1S/C20H38N6O4.C2HF3O2/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;3-2(4,5)1(6)7/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H,6,7)/t15-,16-,17-;/m0./s1
InChI key	WUHGBZVQELGOMH-FRKSIBALSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

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