CAS 138977-28-3; capsazepine - �뵺�羺�ٷ��ַ

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货号

品牌

产品名称

规格

包装、参考价格

C798330

MACKLIN

Capsazepine

10mM in DMSO

598元/1ml;

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储存：-20°C
状态：液体

C872556

MACKLIN

Capsazepine

99%

306元/5mg; 538元/10mg; 1436元/50mg;

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储存：-20℃
状态：白色到灰白色到棕色固体,粉末,或晶体

C191

Sigma-Aldrich

Capsazepine

≥98% (HPLC), solid

2813.53元/5 MG; 9944.77元/25 MG;

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产品说明

应用

辣椒平作为瞬时受体电位香草醛-1(TRPV1)拮抗剂的应用实例：

研究其对辣椒素诱导的胞外信号调节激酶(ERK)磷酸化的影响作用
研究TRPV1在大鼠伤害感受器中枢神经末梢的作用
公牛精子中TRPV1的功能表征

包装

5, 25 mg in glass bottle

生化/生理作用

辣椒平(Capsazepine)是人工合成的辣椒素类似物和瞬时受体电位香草醛-1(TRPV1)拮抗剂。在多种癌症中具有抗增殖和抗癌作用，包括口腔鳞状细胞癌、非小细胞肺癌(NSCLC)、乳腺癌和前列腺癌细胞株(HSC-3、H460、MDA-231和PC-3)。辣椒平可恢复在内毒素血症中受损的肺机能，可作为急性肺损伤(ALI)的潜在治疗药物。

基本信息

经验(实验)分子式	C₁₉H₂₁ClN₂O₂S
分子量	376.90
MDL编号	MFCD00153778
PubChem化学物质编号	24277967
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
颜色	off-white
溶解性	DMSO: >10 mg/mL, clear
储存温度	2-8℃
SMILES string	Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc3ccc(Cl)cc3
InChI	1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
InChI key	DRCMAZOSEIMCHM-UHFFFAOYSA-N
Gene Information	human ... TRPV1(7442), TRPV4(59341) rat ... Trpv1(83810)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

211280

Sigma-Aldrich

Capsazepine-CAS 138977-28-3-Calbiochem

A competitive antagonist of Capsaicin and resiniferatoxin. Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.

5044.39元/10 MG;

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产品说明

一般描述

A competitive antagonist of Capsaicin (Cat. No. 211274) and resiniferatoxin. Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.
A competitive antagonist of the sensory neuron excitants capsaicin (Cat. No. 211274) and resiniferatoxin (Cat. No. 553975). Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers.

包装

10 mg in Plastic ampoule

生化/生理作用

Primary Target
A competitive antagonist of Capsaicin and resiniferatoxin
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

重悬

Unstable in solution; reconstitute just prior to use.

其他说明

Fox, A.J., et al. 1995. Neuroscience 67, 741.
Ellis, J.L., and Undem, B.J. 1994. J. Pharmacol. Exp. Ther. 268, 85.
Walpole, C.S.J., et al. 1994. J. Med. Chem.37, 1942.
Szallasi, A., et al. 1993. J. Pharmacol. Exp. Therap.267, 728.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₉H₂₁ClN₂O₂S
分子量	376.90
MDL编号	MFCD00153778

产品性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	off-white
溶解性	DMSO: soluble methanol: soluble
运输	ambient
储存温度	10-30℃
InChI	1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
InChI key	DRCMAZOSEIMCHM-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

M01458

Fluorochem

Capsazepine

>99%

2794元/10mg; 11088元/50mg;

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基本信息

CAS Number	138977-28-3
MDL Number	MFCD00153778

安全信息

图形或危害标志
危险性说明	H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
防范说明	P233: Keep container tightly closed. P260: Do not breathe . P261: Avoid breathing . P264: Wash hands thoroughly after handling. P271: Use only outdoors or in a well-ventilated area. P280: Wear . P302 + P352: IF ON SKIN: Wash with plenty of soap and water. P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.. P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P321: Specific treatment (see relevant procedures. on this label). P332 + P313: If skin irritation occurs: Get medical advice/ attention. P337 + P313: If eye irritation persists: Get medical advice/attention. P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P362: Take off contaminated clothing and wash before reuse. P403: Store in a well-ventilated place. P403 + P233: Store in a well-ventilated place. Keep container tightly closed. P405: Store locked up. P501: Dispose of contents/container to in accordance with local regulation .