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CAS: 138-39-6
分子式: C7H10N2O2S
分子量: 186.24
中文名称: 
磺胺米隆
对氨甲苯磺酰胺
磺胺灭脓
甲磺灭脓
醋酸磺胺米隆
英文名称: 
-Amino-p-toluenesulfonamide
4-Homosulfanilamide
mafenide
性质描述: 熔点151-152℃。溶于稀酸和稀碱。其盐酸盐([138-37-4])为无色结晶性粉末。熔点256℃。
生产方法: 以乙酰苄胺为原料,经氯磺化、氨化、水解而得。先将乙酰苄胺于35℃加入氯磺酸中,保持55-60℃反应2h,将反应物加入冰水及氯仿中,分去水层,氯仿层为对乙酰苄胺基磺酰氯的氯仿溶液。将氯仿液于30℃滴入氯水中,室温反应2h,过滤得对乙酰苄胺磺酰胺。将其加入20%氢氧化钠溶液,于100-102℃回流5h,加水及活性炭脱色20min,过滤。滤液冷却结晶,过滤,滤饼加适量水溶解,50-60℃加盐酸至pH9.5-10,加活性炭回流20min,过滤,滤液冷却结晶,过滤得对氨甲苯磺酰胺。
用途: 医药中间体。磺胺类药,用于绿脓杆菌及金黄色葡萄球菌感染。
推荐供应商
货号品牌产品名称规格包装、参考价格
M882846MACKLINMafenide95%459元/50mg;   690元/100mg;   咨询
储存:2-8℃
079312Fluorochem4-Aminomethylbenzenesulfonamide95%8998元/1g;   26950元/5g;   40414元/10g;   咨询

基本信息

CAS Number138-39-6
MDL NumberMFCD00072084
Melting Point150-154℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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