CAS 136194-77-9; go 6976 - �뵺�羺�ٷ��ַ

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CAS:

136194-77-9

分子式:

C₂₄H₁₈N₄O

分子量:

377.42

英文名称:

go 6976

用途:

Go6976是一种强效的PKC抑制剂，其对PKC (老鼠大脑), PKCα, and PKCβ1的IC50分别为7.9nM，2.3 nM, 和 6.2 nM 。此外，也是JAK2 和 Flt3的强抑制剂。Go6976对Ca(2+)不依赖性PKC亚型δ，ε，和ζ的激酶活性没有作用。[1]除了WT JAK2，Go6976也会抑制突变型血液恶性肿瘤(JAK2 V617F 和 TEL-JAK2)，且具有抗突变型FLT3的活性。在AML细胞中，Go6976将FLT3-ITD样品中的存活率降低到对照组的55%，FLT3-WT样品中降低为69%。[2] Go 6976有效抑制苔藓抑素1，肿瘤坏死因子α和白细胞介素6诱导的HIV-1。[3]

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

P796128

MACKLIN

Go6976

10mM in DMSO

618元/1ml;

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储存：-20°C

P872912

MACKLIN

Go6976

99%

1635元/5mg;

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储存：-20℃
状态：粉末

365253

Sigma-Aldrich

InSolution Gö 6976-CAS 136194-77-9-Calbiochem

3124.36元/1 ML;

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产品说明

一般描述

Inhibitor of protein kinase C (PKC; IC₅₀ = 7.9 nM for rat brain). Selectively inhibits Ca²⁺-dependent PKC_α-isozyme (IC₅₀ = 2.3 nM) and PKC_βI (IC₅₀ = 6.2 nM). Does not affect the kinase activity of the Ca²⁺-independent PKC δ-, ε-, and ζ-isoenzymes even at micromolar levels. A potent antagonist of HIV-1 induction.

包装

1 ml in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product competes with ATP.
Target IC₅₀: 7.9 nM, 2.3 nM, and 6.2 nM, for rat brain PKC, Ca2+-dependent PKC α-isozyme, and PKCβI, respectively
Reversible: yes
Primary Target
PKC

警告

Toxicity: Irritant (B)

外形

A 500 µg/ml solution of Gö 6976 (Cat. No. 365250) in anhydrous DMSO.

重悬

Following initial thaw, aliquot and freeze (-20°C).

其他说明

Gschwendt, M., et al. 1996. FEBS Lett.392, 77.
Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun.200, 1536.
Martiny-Baron, G., et al. 1993. J. Biol. Chem.268, 9194.
Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA90, 674.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₄H₁₈N₄O
分子量	378.43
MDL编号	MFCD00236434

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	liquid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
溶解性	DMSO: 5 mg/mL
运输	wet ice
储存温度	−20℃
InChI	1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)
InChI key	VWVYILCFSYNJHF-UHFFFAOYSA-N

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 1
闪点(F)	188.6 °F - (Dimethylsulfoxide)
闪点(C)	87 ℃ - (Dimethylsulfoxide)

365250

Sigma-Aldrich

Gö 6976-CAS 136194-77-9-Calbiochem

Gö 6976, CAS 136194-77-9, is a cell-permeable, reversible, and ATP-competitive inhibitor of PKC (IC₅₀ = 7.9 nM for rat brain). Exhibits selectively for PKCα (IC₅₀ = 2

3124.36元/500 μG; 3945.15元/1 MG;

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产品说明

一般描述

A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC; IC₅₀ = 7.9 nM for rat brain). Selectively inhibits Ca²⁺-dependent PKC_α-isozyme (IC₅₀ = 2.3 nM) and PKC_βI (IC₅₀ = 6.2 nM). Does not affect the kinase activity of the Ca²⁺-independent PKC δ-, ε-, and ζ-isoenzymes even at micromolar levels. A potent antagonist of HIV-1 induction.
A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (PKC; IC₅₀ = 7.9 nM for rat brain). Selectively inhibits Ca²⁺-dependent PKC α-isozyme (IC₅₀ = 2.3 nM) and PKC_βI (IC₅₀ = 6.2 nM). Does not affect the kinase activity of the Ca²⁺-independent PKC δ-, ε-, and ζ-isozymes even at micromolar levels. Reported to inhibit PKC_µ at higher concentrations (IC₅₀ = 20 nM). A 500 µg/ml solution of Gö 6976 (Cat. No. 365253) in anhydrous DMSO is also available.

包装

1 mg in Plastic ampoule
500 μg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product competes with ATP.
Target IC₅₀: 7.9 nM against rat brain PKC; 2.3 nM, 6.2 nM against Ca2+-dependent PKC α-isozyme and PKCβI, respectively
Reversible: yes
Primary Target
PKC

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.