CAS 1338575-28-2; wwl229 - �뵺�羺�ٷ��ַ

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CAS:

1338575-28-2

英文名称:

wwl229

4-nitrophenyl 2-(3-methoxypropyl)piperidine-1-carboxylate

2-(3-methoxypropyl)-1-piperidinecarboxylic acid 4-nitrophenyl ester

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货号

品牌

产品名称

规格

包装、参考价格

SML1180

Sigma-Aldrich

WWL229

≥98% (HPLC)

1396.09元/5 MG; 4498.97元/25 MG;

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产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. WWL229 inhibits mCes3 with an IC₅₀ of 10 μM, but not Ces1f, ABHD6 or other tested serine hydrolases. In a recent study, hCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjects, and is thought to generate surplus fatty acids that can deposit ectopically in tissues. WWL229 inhibits adipocyte basal lipolysis and promotes differentiation and lipid storage in adipocytes.

基本信息

经验(实验)分子式	C₁₆H₂₂N₂O₅
分子量	322.36
PubChem化学物质编号	329825704

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	oil
颜色	colorless to light yellow
储存温度	2-8℃
SMILES string	O=C(OC1=CC=C([N+]([O-])=O)C=C1)N2C(CCCOC)CCCC2
InChI	1S/C16H22N2O5/c1-22-12-4-6-13-5-2-3-11-17(13)16(19)23-15-9-7-14(8-10-15)18(20)21/h7-10,13H,2-6,11-12H2,1H3
InChI key	XVBRVSAGMWRVCK-UHFFFAOYSA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

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