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CAS: 129618-40-2
中文名称: 
萘维拉平
奈维拉平
内维拉平
奈韦拉平
那韦拉平
萘未拉平
英文名称: 
nevirapine
推荐供应商
货号品牌产品名称规格包装、参考价格
N0922TCINevirapine>98.0%(GC)860元/200MG;   咨询

基本信息

纯度/分析方法>98.0%(GC)
分子式/分子量C15H14N4O = 266.30
外观与形状(20℃)固体
储存温度<0℃
应避免的情况加热
Reaxys-RN4757598
PubChem物质ID160871291
Merck Index (14)6490
MDL编号MFCD00866928

技术规格

AppearanceWhite to Light yellow powder to crystal
Purity(GC)min. 98.0 %
Purity(Nonaqueous Titration)min. 97.0 %
Melting point244.0 to 248.0 ℃

物性(参考值)

熔点246 ℃
水溶性不溶
在水中的溶解度< 0.1 g/l  

安全信息

图形或危害标志
信号词警告
危险性说明H302 : 吞咽有害。
防范说明P501 : 将内装物/容器送到批准的废物处理厂处理。
P270 : 使用本产品时不要进食、饮水或吸烟。
P264 : 作业后彻底清洗皮肤。
P301 + P312 + P330 : 如误吞咽:如感觉不适,呼叫急救中心/医生。漱口。

相关法规

RTECS#JM5562500
444658J&KNevirapine99%, 非核苷类逆转录酶抑制剂(NNRTI)123元/20MG;   408元/100MG;   咨询

基本信息

分子式C15H14N4O
分子量266.30
熔点244-248
MDL编码MFCD00866928
Beilstein4757598
Merck14,6490
存储条件Freezer -20℃

安全信息

图形或危害标志
提示语Warning
危险说明H302
防范说明P264
P270
P301+P312+P330
P501
WGK2
RTECSJM5562500
PHR1757SupelcoNevirapinePharmaceutical Secondary Standard; Certified Reference Material1166.31元/1 G;   咨询

产品说明

一般描述

药物二级标准品CRM,为制药行业QC实验室及生产质量控制和研发,提供了一种方便、高性价比且符合相关法规的替代方案。奈韦拉平是一种非核苷类逆转录酶抑制剂(NNRTI),属于抗逆转录病毒药物。它通过抑制逆转录酶起作用,从而抑制了 HIV 的繁殖。它对晚期 HIV 疾病非常有效。

应用

奈韦拉平可用作药物参考标准,用于通过色谱法测定药物制剂和固定剂量组合中的分析物。
这些二级标准品是合格的有证标准物质。它们适用用于于多种分析应用,包括但不限于药物释放检测、用于定性和定量分析的药物方法开发、食品和饮料质量控制检测以及其他校准要求。

生化/生理作用

奈韦拉平是 HIV 逆转录酶(NNRTI)的变构非核苷抑制剂。奈韦拉平抑制野生型 RT 的 Ki 为 200 nM。

分析说明

这些二级标准品可溯源到USP、EP和BP一级标准品。

其他说明

该认证参考物质(CRM)根据ISO 17034ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

附注

欲查看此物质的分析证书样本,请在下面的“文本”框中输入LRAA3032。这只是一个示例证书,可能与您收到的批次不符。

基本信息

经验(实验)分子式C15H14N4O
分子量266.30
MDL编号MFCD00866928
PubChem化学物质编号329823596
NACRESNA.24

产品性质

质量水平300
等级certified reference material
pharmaceutical secondary standard
CofAcurrent certificate can be downloaded
包装pkg of 1 g
technique(s)HPLC: suitable
gas chromatography (GC): suitable
application(s)pharmaceutical (small molecule)
格式neat
药典可追溯性traceable to PhEur Y0000520
traceable to USP 1460703
储存温度2-30℃
SMILES stringCC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O
InChI1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
InChI keyNQDJXKOVJZTUJA-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
Y0000520Nevirapine (anhydrous)European Pharmacopoeia (EP) Reference Standard1259.15元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

奈韦拉平是 HIV 逆转录酶(NNRTI)的变构非核苷抑制剂。奈韦拉平抑制野生型 RT 的 Ki 为 200 nM。

包装

Unit quantity: 30 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C15H14N4O
分子量266.30
MDL编号MFCD00866928
PubChem化学物质编号329831001
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O
InChI1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
InChI keyNQDJXKOVJZTUJA-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
Y0000521Nevirapine for peak identificationEuropean Pharmacopoeia (EP) Reference Standard1313.88元/ ;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

奈韦拉平是 HIV 逆转录酶(NNRTI)的变构非核苷抑制剂。奈韦拉平抑制野生型 RT 的 Ki 为 200 nM。

包装

Unit quantity: 0.058 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C15H14N4O
分子量266.30
MDL编号MFCD00866928
PubChem化学物质编号329831002
NACRESNA.24

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameEDQM
application(s)pharmaceutical (small molecule)
格式neat
储存温度2-8℃
SMILES stringCC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O
InChI1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
InChI keyNQDJXKOVJZTUJA-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
SML0097Sigma-AldrichNevirapine1017.76元/10 MG;   4110.38元/50 MG;   咨询

产品说明

应用

Nevirapine has been used as non-nucleoside reverse transcriptase inhibitor in in vitro porcine endogenous retrovirus replication, primary hepatocytes and bone marrow dendritic cells (BMDCs).

包装

10, 50 mg in glass bottle

生化/生理作用

奈韦拉平是 HIV 逆转录酶(NNRTI)的变构非核苷抑制剂。奈韦拉平抑制野生型 RT 的 Ki 为 200 nM。
Nevirapine interacts with glycine 190 residue of human immuno deficiency virus (HIV-2) reverse transcriptase. It is an antiretroviral drug which increases bile synthesis and activates electron transport chain. Use of nevirapine leads to liver toxicity and is associated with Nevirapine hypersensitivity syndrome.

基本信息

经验(实验)分子式C15H14N4O
分子量266.30
MDL编号MFCD00866928
PubChem化学物质编号329825155
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to tan
溶解性DMSO: ≥22 mg/mL
储存温度room temp
SMILES stringCC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O
InChI1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
InChI keyNQDJXKOVJZTUJA-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
1460703USPNevirapine anhydrousUnited States Pharmacopeia (USP) Reference Standard3231.47元/100 MG;   咨询

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

生化/生理作用

奈韦拉平是 HIV 逆转录酶(NNRTI)的变构非核苷抑制剂。奈韦拉平抑制野生型 RT 的 Ki 为 200 nM。

分析说明

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他说明

USP issued SDS can be found here.
Sales restrictions may apply.

基本信息

经验(实验)分子式C15H14N4O
分子量266.30
MDL编号MFCD00866928
PubChem化学物质编号329750549

产品性质

等级pharmaceutical primary standard
manufacturer/tradenameUSP
application(s)pharmaceutical (small molecule)
格式neat
SMILES stringCC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O
InChI1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
InChI keyNQDJXKOVJZTUJA-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable
358078Fluorochem2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10-one0.97220元/1g;   506元/5g;   1694元/25g;   6050元/100g;   咨询

基本信息

CAS Number129618-40-2
MDL NumberMFCD00866928
Melting Point246℃

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: .
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see . on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to local regulations.
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