| è´§å· | å“牌 | 产å“å称 | è§„æ ¼ | 包装ã€å‚è€ƒä»·æ ¼ | |
| D799056 | MACKLIN | D-鞘氨醇 | ≥99% | 206元/25mg; 650元/100mg; 1150元/250mg; | 咨询 |
储å˜ï¼š-20°C, 惰性气体 状æ€ï¼šç™½è‰²ç²‰æœ« |
| D793208 | MACKLIN | D-鞘氨醇 | 10mM in DMSO | 720元/1ml; | 咨询 |
储å˜ï¼š-20°C, 惰性气体 |
| D868242 | MACKLIN | D-鞘氨醇 | ≥96% | 65元/5mg; 120元/25mg; 406元/100mg; 798元/250mg; 2285元/1g; 8500元/5g; | 咨询 |
储å˜ï¼š-20°C 状æ€ï¼šç™½è‰²ç²‰æœ« |
| S0874 | TCI | D-Sphingosine | >96.0%(GC) | 1640元/25MG; | 咨询 |
åŸºæœ¬ä¿¡æ¯ | 纯度/分æžæ–¹æ³• | >96.0%(GC) | | 分åå¼/分åé‡ | C18H37NO2 = 299.50 | | 外观与形状(20℃) | 固体 | | 储å˜æ¸©åº¦ | <0℃ | | 储å˜åœ¨æƒ°æ€§æ°”体下 | å˜æ”¾äºŽæƒ°æ€§æ°”ä½“ä¹‹ä¸ | | 应é¿å…的情况 | 空气,åŠ çƒ | | Reaxys-RN | 1727294 | | PubChem物质ID | 253660322 | | Merck Index (14) | 8747 | | MDLç¼–å· | MFCD00036751 |
æŠ€æœ¯è§„æ ¼ | Appearance | White to Light yellow powder to crystal | | Purity(GC) | min. 96.0 % | | Specific rotation [a]20/D | -0.9 to -3.0 deg(C=1, CHCL3) |
物性(å‚考值) | 熔点 | 74 ℃ | | 比旋光度 [α]D | -2° (C=1,CHCl3) | | 溶解性(微溶于) | 氯仿 |
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| 310919 | J&K | D-Sphingosine | 95% | 355元/5MG; 1420元/25MG; | 咨询 |
åŸºæœ¬ä¿¡æ¯ | 分åå¼ | C18H37NO2 | | 分åé‡ | 299.49 | | MDLç¼–ç | MFCD00036751 | | Beilstein | 1727294 | | EINECS ç¼–å· | 204-651-3 | | å˜å‚¨æ¡ä»¶ | Freezer -20℃ |
å®‰å…¨ä¿¡æ¯ |
| S7049 | Sigma-Aldrich | D-Sphingosine | synthetic | 2068.74元/5 MG; 5809.66元/25 MG; | 咨询 |
产å“说明 应用 å·²ç ”ç©¶äº† D-Sphingosine(åˆæˆçš„)对真èŒèŽ±æ°é‡Žæ‘èŒçš„å‘芽活性的影å“。8 包装 5, 25 mg in glass bottle 生化/生ç†ä½œç”¨ 鞘氨醇的天然异构体
细胞膜的一ç§ç»„æˆéƒ¨åˆ†ã€‚神ç»é…°èƒºçš„å‰ä½“。蛋白激酶 C 的选择性抑制剂，但ä¸æŠ‘制蛋白激酶 A 或肌çƒè›‹ç™½è½»é“¾æ¿€é…¶ã€‚钙调蛋白ä¾èµ–性酶的抑制剂。 åŸºæœ¬ä¿¡æ¯ | ç»éªŒ(实验)分åå¼ | C18H37NO2 | | 分åé‡ | 299.49 | | Beilstein | 1727294 | | EC å· | 204-651-3 | | MDLç¼–å· | MFCD00036751 | | PubChem化å¦ç‰©è´¨ç¼–å· | 24899729 | | NACRES | NA.77 |
产å“性质 | è´¨é‡æ°´å¹³ | 100 | | 生物æ¥æº | synthetic | | 测定 | ≥98% (TLC) | | å½¢å¼ | powder | | mp | 74.2-78.1 ℃ | | 溶解性 | chloroform: complete 20 mg/mL, clear, colorless | | 储å˜æ¸©åº¦ | −20℃ | | SMILES string | OC[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC | | InChI | 1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1 | | InChI key | WWUZIQQURGPMPG-KRWOKUGFSA-N | | Gene Information | rat ... Prkca(24680) |
å®‰å…¨ä¿¡æ¯ | 储å˜åˆ†ç±»ä»£ç | 13 - Non Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable | | 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
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| 860490P | Avanti | Sphingosine (d18:1) | Avanti Polar Lipids | 1718.92元/10 mg; 2441.93元/25 mg; | 咨询 |
产å“说明 一般æè¿° 鞘氨醇 (d18:1) 是å˜åœ¨äºŽåŠ¨æ¤ç‰©ä¸çš„一ç§éž˜æ°¨é†‡éª¨æž¶ã€‚它具有2-氨基-1,3-二醇官能团，并且其较难从动物组织ä¸è¿›è¡Œæå–。 鞘氨醇 (d18:1) å¯ç”±D-åŠä¹³ç³–通过手性方法进行åˆæˆã€‚ 应用 鞘氨醇 (d18:1) 已被用于：
- å°é¼ 鞘氨醇å¸å…¥ç ”究ä¸ï¼Œä»¥è¯„估其在呼å¸é“上皮细胞ä¸çš„治疗潜力
- ç ”ç©¶å…¶å¯¹é“œç»¿å‡å•èƒžèŒèŒæ ªçš„å½±å“
- 作为液相色谱串è”质谱法ä¸çš„æ ‡å‡†å“，用于对表皮神ç»é…°èƒºçš„定é‡
生化/生ç†ä½œç”¨ 鞘氨醇(d18：1)对于包括细胞分化ã€ç”Ÿé•¿å’Œå˜æ´»åœ¨å†…的生ç†è¿‡ç¨‹è‡³å…³é‡è¦ã€‚它å¯æ¿€æ´»çž¬æ€å—体电ä½é˜³ç¦»å通é“亚家æ—æˆå‘˜3(TRPM3)。 包装 5 mLç¥ç€è‰²çŽ»ç’ƒèžºæ—‹ç›–å°ç“¶(860490P-10mg)
20 mLé€æ˜ŽçŽ»ç’ƒèžºæ—‹ç›–å°ç“¶(860490P-500mg)
5 mLç¥ç€è‰²çŽ»ç’ƒèžºæ—‹ç›–å°ç“¶(860490P-25mg) åŸºæœ¬ä¿¡æ¯ | ç»éªŒ(实验)分åå¼ | C18H37NO2 | | 分åé‡ | 299.49 | | NACRES | NA.25 |
产å“性质 | å½¢å¼ | powder | | 包装 | pkg of 1 × 10 mg (860490P-10mg)
pkg of 1 × 25 mg (860490P-25mg)
pkg of 1 × 500 mg (860490P-500mg) | | manufacturer/tradename | Avanti Polar Lipids 860490P | | è¿è¾“ | dry ice | | 储å˜æ¸©åº¦ | −20℃ | | SMILES string | OC[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC | | InChI | 1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1 | | InChI key | WWUZIQQURGPMPG-KRWOKUGFSA-N |
å®‰å…¨ä¿¡æ¯ | 储å˜åˆ†ç±»ä»£ç | 13 - Non Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
|
| 567726 | Sigma-Aldrich | D-erythro-Sphingosine, Free Base, High Purity-CAS 123-78-4-Calbiochem | Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer. | 1954.93元/10 MG; | 咨询 |
产å“说明 一般æè¿° Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer. A potent, cell-permeable, reversible, and selective inhibitor of protein kinase C (PKC; IC50 = 2.8 µM) and insulin receptor tyrosine kinase. PKC inhibition is competitive with respect to diacylglycerol, phorbol dibutyrate, and Ca2+. Does not affect the activity of myosin light chain kinase and protein kinase A. Induces apoptosis in human leukemia HL-60 cells. Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.
Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer. 包装 10 mg in Plastic ampoule 生化/生ç†ä½œç”¨ Target IC50: 2.8 µM against PKC
Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
PKC è¦å‘Š Toxicity: Irritant (B) é‡æ‚¬ Following reconstitution, aliquot, purge with N₂ gas, and freeze (-20°C). Stock solutions are stable for up to 6 months under inert atmosphere at -20°C. æ³•å¾‹ä¿¡æ¯ CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany åŸºæœ¬ä¿¡æ¯ | ç»éªŒ(实验)分åå¼ | C18H37NO2 | | 分åé‡ | 299.49 | | MDLç¼–å· | MFCD00036751 |
产å“性质 | è´¨é‡æ°´å¹³ | 100 | | 测定 | ≥98% (TLC) | | å½¢å¼ | solid | | manufacturer/tradename | Calbiochem® | | 储å˜æ¡ä»¶ | OK to freeze | | 颜色 | white | | 溶解性 | chloroform: 1 mg/mL
methanol: 1 mg/mL
DMSO: 10 mg/mL | | è¿è¾“ | ambient | | 储å˜æ¸©åº¦ | −20℃ | | InChI | 1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1 | | InChI key | WWUZIQQURGPMPG-KRWOKUGFSA-N |
å®‰å…¨ä¿¡æ¯ | 储å˜åˆ†ç±»ä»£ç | 11 - Combustible Solids | | WGK | WGK 3 | | 闪点(F) | Not applicable | | 闪点(C) | Not applicable |
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