CAS 1191-85-1; 5,8,11,14-eicosatetraynoic acid

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货号

品牌

产品名称

规格

包装、参考价格

E938409

MACKLIN

ETYA

≥98%

950元/1mg; 2000元/5mg;

咨询

储存：2-8°C，密封，干燥
状态：白色到棕褐色粉末

E1768

Sigma-Aldrich

5,8,11,14-Eicosatetraynoic acid

≥97%

4220.92元/5 MG;

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产品说明

包装

5 mg in glass bottle

生化/生理作用

Eicosatetraynoic acid (ETYA) is a non-metabolizable analog of ω-6 arachidonic acid. ETYA is a strong activator of the human peroxisome proliferator-activated receptor α (PPARα). It acts as an inhibitor of lipoxygenases (LOX) and cyclooxygenases (COX).
Eicosatetraynoic acid is a lipoxygenase and cyclooxygenase inhibitor.

基本信息

经验(实验)分子式	C₂₀H₂₄O₂
分子量	296.40
Beilstein	1798411
MDL编号	MFCD00036967
PubChem化学物质编号	24894432
NACRES	NA.77

产品性质

质量水平	200
生物来源	synthetic (organic)
测定	≥97%
形式	powder
mp	78-80 ℃
溶解性	ethanol: 50 mg/mL, clear, colorless to yellow
储存温度	−20℃
SMILES string	CCCCCC#CCC#CCC#CCC#CCCCC(O)=O
InChI	1S/C20H24O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-5,8,11,14,17-19H2,1H3,(H,21,22)
InChI key	MGLDCXPLYOWQRP-UHFFFAOYSA-N
Gene Information	human ... ALOX15(246)

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)

434741

Sigma-Aldrich

ETYA-CAS 1191-85-1-Calbiochem

Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases.

4923.29元/20 MG;

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产品说明

一般描述

Cell permeable. Inhibits arachidonic acid uptake and the activities of arachidonic acid specific and non-specific acyl-CoA synthetases. Inhibits phospholipase A₂ (PLA₂) and cytochrome P-450. Inhibits cyclooxygenase (ID₅₀= 8 µM), 5-lipoxygenase (ID₅₀= 10 µM), 12-lipoxygenase (ID₅₀= 300 nM), and 15-lipoxygenase (ID₅₀= 200 nM) in whole cells. Also acts as a potent modulator of Ca²⁺ entry into cells. Blocks monocyte binding in minimally-oxidized LDL in endothelial cells. Stimulates luteinizing hormone release from cultured pituitary cells.
Cell-permeable. Inhibits arachidonic acid uptake and arachidonic acid specific and nonspecific acyl-CoA synthesis. Inhibits phospholipase A₂ (PLA₂) and cytochrome P-450. Inhibits cyclooxygenase (ID₅₀ = 8 µM), 5-lipoxygenase (ID₅₀ = 10 µM), 12-lipoxygenase (ID₅₀ = 300 nM), and 15-lipoxygenase (ID₅₀ = 200 nM) in whole cells. A potent modulator of Ca²⁺ entry into cells. Stimulates luteinizing hormone release from cultured pituitary cells.

包装

20 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target IC₅₀: 8 µM, 10 µM, 300 nM, 200 nM against cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase, and 15-lipoxygenase , respectively, in whole cells
Primary Target
PLA₂

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Honda, H.M., et al. 1999. Arterioscler. Thromb. Vasc. Biol.19, 680.
Ekokoski, E., and Tornquist, K. 1994. Biochim. Biophys. Acta 1223, 274.
Ondrey, F., et al. 1989. Cancer Res.49, 1138.
Kuhn, H., et al. 1984. Eur. J. Biochem.139, 577.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₀H₂₄O₂
分子量	296.40
MDL编号	MFCD00036967

产品性质

质量水平	100
测定	≥95% (TLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	off-white
溶解性	ethanol: 20 mg/mL DMSO: soluble
运输	ambient
储存温度	−20℃
InChI	1S/C20H24O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-5,8,11,14,17-19H2,1H3,(H,21,22)
InChI key	MGLDCXPLYOWQRP-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable