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CAS: 118-04-7
分子式: C14H10ClNO3
分子量: 275.69
沸点: 538.6°C
中文名称: 
2-(3-氨基-4-氯苯甲酰)苯甲酸
2'-羧基-3-氨基-4-氯代二苯甲酮
英文名称: 
2-(3-amino-4-chlorobenzoyl)-benzoic aci
2-(3-amino-4-chlorobenzoyl)benzoic acid
(3-Amino-4-Chlorophenyl)(2'-Carboxylphenyl)methanone
性质描述: 熔点174-176℃。
生产方法: 将2-(4-氯苯甲酰)苯甲酸用混酸硝化、铁粉还原而得:向硝化锅加入98%硫酸,加入2-(4-氯苯甲酰)苯甲酸,在30-40℃搅拌至全溶。在0.5-1.0h内将硝酸缓缓加入,控制温度30-40℃。加完反应5min。加水稀释,过滤,水洗至中性,得硝化物熔点194℃以上。将硝化物加入溶解锅内的水中,再加入30%液碱,控制pH=6.7,在90℃左右使硝化物全部溶解。另在还原锅中加水,加热到80℃,加入40目铁屑及氯化铵,加热到95℃以上,将溶解锅内的2-(4-氯-3-硝基苯甲酰)苯甲酸钠盐溶液在1h渐渐加入还原锅,反应在沸腾下进行。加完后保持沸腾反应15min,静置,过滤,滤渣用碱性热水充分洗涤。滤洗液在40-50℃用浓硫酸酸析,过滤,滤饼水洗,烘干,得干品。熔点175℃以上,含量95%以上。硝化还原反应总收率83%。
用途: 医药和染料的中间体。用于生产药物氯噻酮和还原蓝BC。
推荐供应商
货号品牌产品名称规格包装、参考价格
A843800MACKLIN2-(3-氨基-4-氯苯甲酰)苯甲酸97%71元/1g;   124元/10g;   咨询
储存:2-8°C
215728Fluorochem2-(3-amino-4-chlorobenzoyl)benzoic acid95%264元/10g;   484元/25g;   1518元/100g;   咨询

基本信息

CAS Number118-04-7
MDL NumberMFCD00007672

安全信息

图形或危害标志
危险性说明 H302: Harmful if swallowed.
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
防范说明 P233: Keep container tightly closed.
P260: Do not breathe .
P261: Avoid breathing .
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear .
P301 + P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P304: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing..
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P321: Specific treatment (see relevant procedures. on this label).
P330: Rinse mouth.
P332 + P313: If skin irritation occurs: Get medical advice/ attention.
P337 + P313: If eye irritation persists: Get medical advice/attention.
P340: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P362: Take off contaminated clothing and wash before reuse.
P403: Store in a well-ventilated place.
P403 + P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.
P501: Dispose of contents/container to in accordance with local regulation .
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