CAS 1109276-89-2; pf-04620110 - �뵺�羺�ٷ��ַ

位置：首页 > 资料中心 > 化工字典 > 1109276-89-2

CAS:

1109276-89-2

分子式:

C₂₁H₂₄N₄O₄

分子量:

396.44

英文名称:

pf-04620110

trans-4-[4-(4-amino-7,8-dihydro-5-oxopyrimido[5,4-f][1,4]oxazepin-6(5h)-yl)phenyl]-cyclohexaneacetic acid

用途:

PF-04620110是一种口服有效的，选择性甘油二酯酰基转移酶-1(DGAT1)抑制剂，IC50为19 nM。

推荐供应商

货号

品牌

产品名称

规格

包装、参考价格

P872562

MACKLIN

PF-04620110

99%

360元/5mg; 1172元/25mg;

咨询

储存：-20℃
状态：粉末

P794015

MACKLIN

PF-04620110

10mM in DMSO

557元/1ml;

咨询

储存：-20°C

PZ0207

Sigma-Aldrich

PF-04620110

≥98% (HPLC)

1179.67元/5 MG; 4776.54元/25 MG;

咨询

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

PF-04620110 is known to regulate gut hormones. Inhibition of DGAT1 might serve as a good approach for the treatment of obesity and type 2 diabetes. DGAT1 inhibition might increase the oxidation of fatty acids, thus it is found to be protective against hepatic steatosis.
PF-04620110 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that inhibits triacylglycerol synthesis in cells and in rodents.

其他说明

This compound was developed by Pfizer for Lipid Signaling research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式	C₂₁H₂₄N₄O₄
分子量	396.44
PubChem化学物质编号	329823775
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
manufacturer/tradename	Pfizer^®
颜色	white to beige
溶解性	DMSO: 10 mg/mL (clear solution)
创始人	Pfizer
储存温度	room temp
SMILES string	Nc1ncnc2OCCN(C(=O)c12)c3ccc(cc3)[C@@H]4CC[C@H](CC4)CC(O)=O
InChI	1S/C21H24N4O4/c22-19-18-20(24-12-23-19)29-10-9-25(21(18)28)16-7-5-15(6-8-16)14-3-1-13(2-4-14)11-17(26)27/h5-8,12-14H,1-4,9-11H2,(H,26,27)(H2,22,23,24)/t13-,14-
InChI key	GEVVQZHMFVFGLN-HDJSIYSDSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
危险分类	Acute Tox. 4 Oral
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable

CAS号首数字顺序排列： 1 2 3 4 5 6 7 8 9