靶标９�p style="text-indent: 2em;">METTL4

产品别名９�p style="text-indent: 2em;">HsT661� METTL4� methyltransferase 4, N6-adenosine� methyltransferase 4, N6-adenosine� N(6)-adenine-specific methyltransferase METTL4� N(6)-adenine-specific DNA methyltransferase METTL4� methyltransferase like 4� methyltransferase-like protein 4� snRNA (2'-O-methyladenosine-N(6)-)-methyltransferase METTL4� 甲基化样蛋白4�

背景信息９�div style="text-indent: 2em;">N(6-adenine-specific methyltransferase that can methylate both RNAs and DNA. Acts as a N(6-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m on internal positions of U2 small nuclear RNA (snRNA: methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation. Internal m6A(m methylation of snRNAs regulates RNA splicing. Also able to act as a N(6-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6-methyladenosine. The existence of N(6-methyladenosine (m6A on DNA is however unclear in mammals, and additional evidences are required to confirm the role of the N(6-adenine-specific DNA methyltransferase activity of METTL4 in vivo. Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA copy number by mediating mtDNA N(6-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending. N(6-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (By similarity.