靶标９�p style="text-indent: 2em;">PCDH12

产品别名９�p style="text-indent: 2em;">DMJDS1� VE-cadherin-2� VECAD2� PCDH12� protocadherin 12� protocadherin 12� protocadherin-12� VE-cad-2� VE-cadherin 2� vascular cadherin-2� vascular endothelial cadherin 2� 原钙粘附蛋白12/血管内皮钙粘蛋�?� 原钙黏素12(PCDH12)�

背景信息９�div style="text-indent: 2em;">Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 12 (PCDH12) was initially identified through PCR screening of mouse heart microvascular endothelial cell RNA; further experiments revealed its mRNA to be strongly expressed in highly vascularized organs such as lung and kidney, in addition to glycogen-rich trophoblasts in the placenta. PCDH12-null mice are viable and fertile, but show reduced placental and embryonic sizes when compared to wild-type mice. Further studies showed significant expression changes in 2, 289 genes, including those involved in tissue morphogenesis, angiogenesis, cell-matrix adhesion and migration, immune response and chromatin remodeling.