靶标９�p style="text-indent: 2em;">FRAT2

产品别名９�p style="text-indent: 2em;">FRAT-2� FRAT2� FRAT regulator of WNT signaling pathway 2� FRAT regulator of WNT signaling pathway 2� GSK-3-binding protein FRAT2� FRAT2, WNT signaling pathway regulator� frequently rearranged in advanced T-cell lymphomas 2� GSK-3结合蛋白FRAT2�

背景信息９�div style="text-indent: 2em;">FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.