靶标９�p style="text-indent: 2em;">SPTBN2

产品别名９�p style="text-indent: 2em;">GTRAP41� SCA5� SCAR14� SPTBN2� spectrin beta, non-erythrocytic 2� spectrin beta, non-erythrocytic 2� spectrin beta chain, non-erythrocytic 2� beta-III spectrin� glutamate transporter EAAT4-associated protein 41� spectrin beta III sigma 2� spectrin beta chain, brain 2� spectrin, non-erythroid beta chain 2� spinocerebellar ataxia 5 protein� 非红细胞血影脑蛋白β2/spectrinβIII�

背景信息９�div style="text-indent: 2em;">Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009],