靶标９�p style="text-indent: 2em;">PCDHGC3

产品别名９�p style="text-indent: 2em;">PC43� PCDH-GAMMA-C3� PCDH2� PCDHGC3� protocadherin gamma subfamily C, 3� protocadherin gamma subfamily C, 3� protocadherin gamma-C3� cadherin-like 2� protocadherin 43� protocadherin-2� 原钙粘蛋白γC3�

背景信息９�div style="text-indent: 2em;">This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.