靶标９�p style="text-indent: 2em;">FPGS

产品别名９�p style="text-indent: 2em;">FPGS� folylpolyglutamate synthase� folylpolyglutamate synthase� folylpolyglutamate synthase, mitochondrial� folylpoly-gamma-glutamate synthetase� tetrahydrofolate synthase� tetrahydrofolylpolyglutamate synthase� 叶酰聚谷氨酸合酶(FPGS)� 叶酸盐多谷氨酸合成酶�

背景信息９�div style="text-indent: 2em;">Swiss-Prot Acc.Q05932.Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.