靶标９�p style="text-indent: 2em;">DIO1

产品别名９�p style="text-indent: 2em;">5DI� THMA2� TXDI1� DIO1� iodothyronine deiodinase 1� iodothyronine deiodinase 1� type I iodothyronine deiodinase� DIOI� deiodinase, iodothyronine type I� iodothyronine deiodinase type 1� selenoprotein DIO1� thyroxine 5'-deiodinase� thyroxine deiodinase type I (selenoprotein)� type 1 DI� type-I 5'-deiodinase� 碘甲腺原氨酸脱碘酶Ⅰ(DIO1)�

背景信息９�div style="text-indent: 2em;">Type I iodothyronine deiodinase is a protein that in humans is encoded by the DIO1 gene. It is mapped to 1p32.3. The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.