靶标９�p style="text-indent: 2em;">ASIP

产品别名９�p style="text-indent: 2em;">AGSW� AGTI� AGTIL� ASP� SHEP9� ASIP� agouti signaling protein� agouti signaling protein� agouti-signaling protein� agouti signaling protein, nonagouti homolog� agouti switch protein� nonagouti homolog�

背景信息９�div style="text-indent: 2em;">In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.