蛋白质/抗原/多肽 >> 重组蛋白
重组NFKB激活蛋白
半岛bd体育手机客户端 介绍
基因名:
Nkap 半岛bd体育手机客户端 别名: 2610020O08Rik; AA987160; AI849147; AL024236; Nkap; NFKB activating protein; NFKB activating protein; NF-kappa-B-activating protein; nuclear NF-kappaB activating protein; NFKB激活蛋白; NFKB激活蛋白(NKAP); 背景信息:
NFκB, a pleiotropic transcription factor, is present in almost all cell types and is involved in many biological processes including inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFκB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFκB1/p105, NFκB1/p50, REL and NFκB2/p52. This complex is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NKAP (NF-κ-B-activating protein) is a 415 amino acid nuclear protein that regulates TNF and IL1-induced NFκB activation. As component of a DNA-binding complex, NKAP also functions as a transcriptional repressor that acts on NOTCH target genes. Loss of NKAP blocks the development of αβT- cells, suggesting that it is required for their maturation through repression of NOTCH genes.
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