蛋白质/抗原/多肽 >> 重组蛋白
重组低密度脂蛋白相关蛋白2结合蛋白
半岛bd体育手机客户端 介绍
基因名:
LRP2BP 半岛bd体育手机客户端 别名: LRP2BP; LRP2 binding protein; LRP2 binding protein; LRP2-binding protein; megBP; megalin-binding protein; 低密度脂蛋白相关蛋白2结合蛋白; 背景信息:
?LRP2BP is a 347 amino acid protein that contains one TPR repeat and six Sel1-like repeats. Localized to the plasma membrane and throughout the cytoplasm, LRP2BP interacts with megalin (also known as LRP2) and, via this interaction, is thought to regulate megalin function. Specifically, LRP2BP acts as a scaffold protein that, through its TPR motifs, assists in the sequestration and/or the release of transcription factors that influence megalin’s affects on endocytosis and hormone release. LRP2BP is expressed in colon, testis, small intestine and blood leukocytes, as well as in pancreatic adenocarcinoma cells, suggesting a possible role for LRP2BP in carcinogenesis. Two isoforms of LRP2BP exist due to alternative splicing events.
标签:His-tag |
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