蛋白质/抗原/多肽 >> 重组蛋白
重组O-岩藻糖肽3-β-N-乙酰氨基葡萄糖转移酶(RFNG)蛋白
半岛bd体育手机客户端 介绍
基因名:
RFNG 半岛bd体育手机客户端 别名: RFNG; RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; beta-1,3-N-acetylglucosaminyltransferase radical fringe; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; radical fringe homolog; O-岩藻糖肽3-β-N-乙酰氨基葡萄糖转移酶(RFNG); β1,3-N-乙酰糖基转移酶; 背景信息:
Three mammalian fringe family members, Manic, Radical and Lunatic Fringe, have been identified as proteins related to Drosophila Fringe, a protein involved in development. Fringe proteins act upstream of the Notch signaling pathway and are involved in boundary determination during segmentation. Each mammalian Fringe displays different patterns of expression, though all are expressed in the mouse embryo as well as in many adult tissues. Radical Fringe, also known as Beta-1,3-N-acetylglucosaminyltransferase Radical Fringe, is a 331 amino acid single-pass type II membrane protein that localizes to the membrane of the Golgi apparatus. Playing a key role in the development of the limb bud, Radical Fringe transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor. Lunatic Fringe is required for normal somite segmentation and patterning and is thought to be a target of the molecular clock. Manic Fringe, also involved in somatic development, has been shown to render mouse NIH/3T3 cells tumorigenic in SCID mice.
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