蛋白质/抗原/多肽 >> 重组蛋白
重组脑特定蛋白Brn3B
半岛bd体育手机客户端 介绍
基因名:
POU4F2 半岛bd体育手机客户端 别名: BRN3.2; BRN3B; Brn-3b; POU4F2; POU class 4 homeobox 2; POU class 4 homeobox 2; POU domain, class 4, transcription factor 2; Brn3b POU domain transcription factor; POU domain protein; brain-3B; brain-specific homeobox/POU domain protein 3B; 脑特定蛋白Brn3B; 背景信息:
The Brn family of transcription factors are found in a highly restricted subset of neurons and are critical to the early embryonic development of the central nervous system. Brn-1 and Brn-2 are class III POU (Pit-Oct-Unc) domain proteins, whereas Brn-3 is a class IV POU domain protein. Three Brn-3 proteins have been described and are designated Brn-3a, Brn-3b and Brn-3c. While Brn-3a and Brn-3c stimulate transcription, Brn-3b generally functions as a transcriptional repressor. However, Brn-3b, but not Brn-3a, has been shown to regulate the expression of the acetylcholine receptor. Interestingly, Brn-3a has two functional transactivating domains, one at the amino-terminus and one at the carboxy-terminus. Brn-2 is thought to be involved in smooth muscle cell development and differentiation.
标签:His-tag |
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