蛋白质/抗原/多肽 >> 重组蛋白
重组铜转运蛋白2
半岛bd体育手机客户端 介绍
基因名:
SLC31A2 半岛bd体育手机客户端 别名: COPT2; CTR2; hCTR2; SLC31A2; solute carrier family 31 member 2; solute carrier family 31 member 2; probable low affinity copper uptake protein 2; copper transporter 2; solute carrier family 31 (copper transporter), member 2; solute carrier family 31 (copper transporters), member 2; 铜转运蛋白2; 背景信息:
The activity of a diverse subset of enzymes relies on the essential nutrient copper to perform important processes including signaling to the transcription and protein trafficking machinery, oxidative phosphorylation, iron mobilization, neuropeptide maturation, and normal development. Copper uptake requires tight regulation to ensure that sufficient copper is present in the cell to drive vital cellular processes, while avoiding the accumulation of copper to toxic levels. The copper transporter 2 (COPT2), also designated CTR2 or Solute carrier family 31 member 2 (SLC31A2), is a 143 amino acid protein mediates the uptake of copper in mammalian cells. COPT2 has been shown to localize to the plasma membrane, endosomes and lysosomes, where it plays a role in maintaining copper homeostasis. COPT2 also mediates the uptake of the chemotherapeutic drugs cisplatin and carboplatin and may modulate the sensitivity and toxicity of these drugs.
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