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鸟苷酸环化酶α2/GCS-α-2抗体
鸟苷酸环化酶α2/GCS-α-2抗体图片
交货期: 1周
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交货期: 1周
半岛bd体育手机客户端 别名: Anti-GUCY1A2
Anti-guanylate cyclase 1 soluble subunit alpha 2 Antibody
半岛bd体育手机客户端 介绍
靶标:

GUCY1A2


半岛bd体育手机客户端 别名:

GC-SA2; GUC1A2; GUCY1A2; guanylate cyclase 1 soluble subunit alpha 2; guanylate cyclase 1 soluble subunit alpha 2; guanylate cyclase soluble subunit alpha-2; GCS-alpha-2; guanylate cyclase 1, soluble, alpha 2; 鸟苷酸环化酶α2/GCS-α-2;


背景信息:
Guanylate cyclases belong to the adenylyl cyclase class-4 guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide (NO). The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide. It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme-containing heterodimer, consisting of one alpha subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide (CO), which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1 beta-1 and alpha-2 beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver.

宿主:Rbt
类型:Pab
同种型:IgG
应用:WB
纯化方式:亲和纯化
偶联物:Unconjugated
性状:液体
存储溶液:参阅说明书
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存:经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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