半岛bd体育手机客户端 介绍
靶标：
DPH1 半岛bd体育手机客户端 别名： DEDSSH； DPH2L； DPH2L1； OVCA1； DPH1； diphthamide biosynthesis 1； diphthamide biosynthesis 1； 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1； DPH-like 1； DPH1 homolog； DPH2-like 1； S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1； candidate tumor suppressor in ovarian cancer 1； diphthamide biosynthesis protein 1； diphthamide biosynthesis protein 2 homolog-like 1； diphtheria toxin resistance protein 1； diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1； ovarian cancer-associated gene 1 protein； ovarian tumor suppressor candidate 1； 卵巢癌相关基因1； 背景信息：
OVCA1 is required for the first step in the synthesis of diphthamide, a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. OVCA1 is one of several enzymes involved in synthesis of diphthamide in EEF2.
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